Monday, 22 November 2010

2,4-Dinitrophenol - The anti obesity drug thats been known since 1930

This report makes for a very interesting read and it looks like uncoupling proteins could be the answer for fat loss.

Thursday, 18 November 2010

Sunday, 14 November 2010

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

"Plasma concentrations of amino acids are frequently elevated in insulin-resistant states, and a protein-enriched diet can impair glucose metabolism"

"In conclusion, plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation, resulting in marked reduction of glycogen synthesis"

Saturday, 13 November 2010

Surplus dietary tryptophan inhibits stress hormone kinetics and induces insulin resistance in pigs

"In conclusion, long-term feeding of surplus dietary TRP inhibits both baseline adrenocortical and sympathetic nervous system activity, it induces insulin resistance for both glucose and amino acid clearance but it does not affect whole body protein catabolism"

Move support not to over-indulge in the protein.

Low-carbohydrate diet disrupts the association between insulin resistance and weight gain.

"the heavier animals that were fed LFD had impairment in insulin sensitivity, which was not observed in those fed LCD"

"The weight gain in animals fed LCD may be related to their greater caloric intake, lower levels of glucagon-like peptide-1, and higher protein consumption"

"The adoption of LCD promotes a unique metabolic state that prevents insulin resistance, even in guinea pigs that gained more weight."

"The association between weight gain and insulin resistance seems to be dependent on high carbohydrate intake"

Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats

Good news for coconut oil I guess?

Diet-induced obese mice are leptin insufficient after weight reduction.

This is scary news for people who lose weight by dieting and helps explains why people gain fat mass back.

Get your leptin checked after loosing weight by dieting.

Dietary branched-chain amino acids and protein selection by rats.

"Although BCAA concentrations were high in plasma and brain in all experiments, concentrations of methionine, tyrosine, phenylalanine, tryptophan and histidine were low in brain in experiments in which rats altered their diet or protein selection after BCAA addition."

More evidence against supplementing BCAA?

Monday, 8 November 2010

Protein and Insulin Resistence

Also this excellent thread explains alot

Saturday, 6 November 2010

Diet-induced ketosis increases capillary density without altered blood flow in rat brain.

Also we have

"These data indicate that adaptation to hypoxia did not interfere with ketosis, and that ketosis during hypoxia may lower lactate levels in brain, suggesting decreased glycolysis or increased glucose disposal."

Immediate metabolic availability of dietary fat in combination with carbohydrate.

After reading all the related studies on a pubmed search to this study, it is clear that dietary fat is handled before dietary carbs if combined in the same meal.

Further, it appears that dietary fat is primed for usage as fuel immediately, and that adipocytes promptly actually start taking up FFA from the blood to reform them into trigs.

Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period.

"In this study, the most striking findings were the postprandial uptake of fatty acids from the circulating NEFA pool by adipose tissue, the direct confirmation that chylomicrons are the preferred substrate of LPL over VLDL, the preferential channeling of fatty acids derived from LPL-mediated chylomicron hydrolysis into adipose tissue, and the postprandial release of fatty acids across the forearm."

So it looks like it is bad news to combine meals that are both high in fat and carbs. The result will be lots of vLDL particules swimming around in your blood.

Friday, 5 November 2010

The Hexosamine Pathway

Currently there is no wikipedia page for this part of biochemistry and knowledge of it still appears to be developing. It seems to be related to insulin signalling and insulin resistence, and over-expression of the pathway seems to cause IR as suggested by this paper.

This next study was also an interesting find, some AA's are produced in vivo in adipocytes, glutamine being one.

Tuesday, 2 November 2010

Its still working

Still having good success with the below training protocol. After using it for the leg press I suffered severe DOMS for 3 days , 2 of those days i could barely walk.

However, I did feel a good response in hypertrophy. My quads and hamstrings felt noticably bigger, just from 1 session.